Antiviral Therapeutics: Graphene Oxide Nanosheets Interact and Interfere with SARS‐CoV‐2 Surface Proteins and Cell Receptors to Inhibit Infectivity (Small 25/2021)

Mehmet Altay Unal; Fatma Bayrakdar; Hasan Nazir; Omur Besbinar; Cansu Gurcan; Neus Lozano; Luis M. Arellano; Süleyman Yalcin; Oguzhan Panatli; Dogantan Celik; Damla Alkaya; Aydan Agan; Laura Fusco; Serap Suzuk Yildiz; Lucia Gemma Delogu; Kamil Can Akcali; Kostas Kostarelos; Açelya Yilmazer

doi:10.1002/smll.202170123

journal article·2021-06

Antiviral Therapeutics: Graphene Oxide Nanosheets Interact and Interfere with SARS‐CoV‐2 Surface Proteins and Cell Receptors to Inhibit Infectivity (Small 25/2021)

Mehmet Altay Unal, Fatma Bayrakdar, Hasan Nazir, Omur Besbinar, Cansu Gurcan, Neus Lozano, Luis M. Arellano, Süleyman Yalcin, Oguzhan Panatli, Dogantan Celik, Damla Alkaya, Aydan Agan, Laura Fusco, Serap Suzuk Yildiz, Lucia Gemma Delogu, Kamil Can Akcali, Kostas Kostarelos, Açelya Yilmazer

Small· Volume 17· Issue 25

Publisher page

Source abstract

Abstract

In article number 2101483, Kostas Kostarelos, Açelya Yilmazer, and co-workers report that thin, biological-grade graphene oxide (GO) nanosheets show molecular affinity toward the SARS-CoV-2 viral spike and the ACE2-bound spike complex. GO nanosheets were shown to inhibit the infection of wild-type SARS-CoV-2 experimentally in cell cultures. Through an interplay of molecular dynamics simulations and cell biology, this work demonstrates that graphene oxide sheets could offer a platform to effectively interact and potentially transport other molecules to inactivate SARS-CoV-2.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Stem Cell Institute Ankara University Balgat Ankara 06520 Turkey

Ministry of Health General Directorate of Public Health Microbiology References Laboratory Sihhiye Ankara 06430 Turkey

Department of Chemistry Ankara University Tandogan Ankara 06100 Turkey

Department of Biomedical Engineering Ankara University Golbasi Ankara 06830 Turkey

Catalan Institute of Nanoscience and Nanotechnology (ICN2) UAB Campus Bellaterra Barcelona 08193 Spain

Department of Biomedical Sciences University of Padua Padua 35122 Italy

Department of Biophysics Faculty of Medicine Ankara University Sihhiye Ankara 06230 Turkey

Nanomedicine Lab National Graphene Institute and Faculty of Biology Medicine & Health The University of Manchester AV Hill Building Manchester M13 9PT United Kingdom

References

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