Spatial Genomics: Mapping Spatial Genetic Landscapes in Tissue Sections through Microscale Integration of Sampling Methodology into Genomic Workflows (Small 23/2021)
Source abstract
Abstract
The GeneScape workflow, presented in article number 2007901 by Govind V. Kaigala and co-workers, uses a modular multipurpose microfluidic probe to facilitate evaluation of spatial genomic heterogeneity in tumors. Cancer cells essentially contain the same genomic blueprint but accumulate distinct corruptions at different spatial and temporal coordinates. Since these cells reside in several interacting ecosystems, it becomes very critical to study the spatial mutational landscape to evaluate and quantify tumor progression.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Molecular Biology Techniques and Applications
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Affiliations
IBM Research Europe Säumerstrasse 4 Rüschlikon CH‐8803 Switzerland
Functional Genomics Center Zurich Winterthurerstr. 190 Zurich CH‐8057 Switzerland
Center for Genomics and Transcriptomics Paul‐Ehrlich‐Str. 23 72076 Tübingen Germany
Department of Pathology and Molecular Pathology University Hospital Zurich Schmelzbergstr. 12 Zurich CH‐8091 Switzerland
References
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