DataVXSmallPaper
journal article·2021-02

Heart on A Chip: Label‐Free Isolation and Single Cell Biophysical Phenotyping Analysis of Primary Cardiomyocytes Using Inertial Microfluidics (Small 8/2021)

Hossein Tavassoli, Prunella Rorimpandey, Young Chan Kang, Michael Carnell, Chris Brownlee, John E Pimanda, Peggy P.Y. Chan, Vashe Chandrakanthan

Small· Volume 17· Issue 8
Publisher page
Source abstract

Abstract

In article number 2006176, Peggy P. Y. Chan, Vashe Chandrakanthan, and co-workers develop a label-free method to purify beating cardiomyocytes from neonatal mouse hearts using a simple particle size-based inertial microfluidics biochip. Biophysical phenotyping analysis of these sorted cardiomyocytes show distinct and consistent physico-mechanical and cellular phenotypes of primary cardiomyocytes. This isolation and phenotyping method will serve as a valuable tool to progress our understanding towards regenerative medicine, drug development and diagnostic applications.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: 3D Printing in Biomedical Research

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Affiliations

Department of Telecommunications, Electrical Robotics and Biomedical Engineering Swinburne University of Technology Hawthorn Victoria 3122 Australia

Department of Pathology School of Medical Sciences University of New South Wales Sydney NSW 2052 Australia

Adult Cancer Program Lowy Cancer Research Centre University of New South Wales Sydney NSW 2052 Australia

Biomedical Imaging Facility Mark Wainwright Analytical Centre University of New South Wales Sydney NSW 2052 Australia

Flow Cytometry Facility Mark Wainwright Analytical Centre University of New South Wales Sydney NSW 2052 Australia

Prince of Wales Clinical School University of New South Wales Sydney NSW 2052 Australia

Department of Haematology Prince of Wales Hospital Sydney NSW 2052 Australia

References

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