Biomorphs: Complex Morphogenesis by a Model Intrinsically Disordered Protein (Small 51/2020)

In article number 2005191, José Carlos Rodríguez-Cabello and co-workers report micrometric colporate biomorphs self-assembled from an intrinsically disordered silk-elastin-like protein, in which the concurrent effect of hydrophobic, electrostatic and H-bonding interactions are capable of generating and kinetically trapping complex and transient structures in time during desolvation processes. This platform provides a novel approach to understand the order-disorder crosstalk and participating interactions in the self-organization process of native proteins in living organisms and how they develop morphology.