Protein Thermodynamic Stability: On‐Chip Acousto Thermal Shift Assay for Rapid and Sensitive Assessment of Protein Thermodynamic Stability (Small 41/2020)
Source abstract
Abstract
In article number 2003506, Xiaoyun Ding and co-workers present an acousto thermal shift assay (ATSA) utilizing acoustic mechanisms to denature proteins and concentrate protein precipitates for rapid and label-free assessment of protein thermodynamic changes in real time. The whole process, including sample handling, protein unfolding, and measurement, takes place within a microfluidic chip in less than two minutes, and is faster than other current thermal shift assays.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Chemical Sensor Technologies · Metabolomics and Mass Spectrometry Studies · Spectroscopy Techniques in Biomedical and Chemical Research
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Affiliations
Paul M. Rady Department of Mechanical Engineering University of Colorado Boulder CO 80309 USA
Department of Molecular Cellular and Developmental Biology University of Colorado Boulder CO 80309 USA
Department of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora CO 80045 USA
References
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