DataVXSmallPaper
journal article·2019-05Open access

Cryo‐Electron Microscopy: Cryo‐EM‐On‐a‐Chip: Custom‐Designed Substrates for the 3D Analysis of Macromolecules (Small 21/2019)

Nick A. Alden, A. Cameron Varano, William J. Dearnaley, Maria J. Solares, William Y. Luqiu, Yanping Liang, Zhi Sheng, Sarah M. McDonald, John Damiano, Jennifer McConnell, Madeline J. Dukes, Deborah F. Kelly

Small· Volume 15· Issue 21
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Source abstract

Abstract

In article number 1900918, Deborah F. Kelly and co-workers develop a new cryo-electron microscopy (EM)-on-a-chip approach. This strategy enables researchers to directly visualize the “fault in our stars” regarding cancer proteins. The structural assemblies of p53 from brain cancer cells are determined for the first time using the microchip-based technique. Artistic rendition by Daryl N. Branford.
Source: openalex_inverted_index · Quality: baseline

Research context

Polymers

OpenAlex topics: Advanced Electron Microscopy Techniques and Applications · RNA modifications and cancer · Circular RNAs in diseases

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Virginia Tech Carilion Research Institute Virginia Tech Roanoke VA 24016 USA

Department of Biomedical Engineering Pennsylvania State University University Park PA 16802 USA

Center for Structural Oncology Pennsylvania State University University Park PA 16802 USA

Translational Biology Medicine, and Health Graduate Program Virginia Tech Blacksburg VA 24061 USA

Huck Institutes of the Life Sciences Pennsylvania State University University Park PA 16802 USA

Department of Biology Wake Forest University Winston‐Salem NC 27109 USA

Application Science Protochips Inc. Morrisville NC 27560 USA

References

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