DataVXSmallPaper
journal article·2019-04Open access

Cancer Diagnostics: Visual Quantitative Detection of Circulating Tumor Cells with Single‐Cell Sensitivity Using a Portable Microfluidic Device (Small 14/2019)

Mahlet Fasil Abate, Shasha Jia, Metages Gashaw Ahmed, Xingrui Li, Li Lin, Xiaoqian Chen, Zhi Zhu, Chaoyong Yang

Small· Volume 15· Issue 14
Publisher pageOpen full text
Source abstract

Abstract

In article number 1804890, Zhi Zhu and co-workers realize visual quantitative detection of circulating tumor cells (CTCs) using a portable volumetric bar chart chip (V-Chip) with singlecell sensitivity. The target CTCs are labeled with aptamer conjugated nanoparticles that can catalyze the generation of oxygen for the movement of an ink bar in the V-Chip. The CTC number is quantified by the distance of the ink bar visually. This portable detection method shows great potential for quantification of rare cells with single-cell sensitivity for various applications.
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Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: 3D Printing in Biomedical Research · Cancer Cells and Metastasis

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Affiliations

The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation The Key Laboratory of Chemical Biology of Fujian Province The Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials Department of Chemical Engineering Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China

Institute of Molecular Medicine Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China

References

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