DataVXSmallPaper
journal article·2019-01Open access

Protein Nanoparticles: A Novel Self‐Assembled Mitochondria‐Targeting Protein Nanoparticle Acting as Theranostic Platform for Cancer (Small 2/2019)

Xin‐Jie Zhu, Ri‐Fei Li, Liang Xu, Hui Yin, Long Chen, Ye Yuan, Wu Zhong, Jian Lin

Small· Volume 15· Issue 2
Publisher pageOpen full text
Source abstract

Abstract

In article number 1803428, Jian Lin and co-workers report the discovery of a novel self-assembled metal protein nanoparticle, designated GST-MT-3, which targets the mitochondria of cancer cells within 30 min in vitro and rapidly accumulates in tumors within 1 h in vivo. The little men carrying the bombs represent GST-MT3 protein nanoparticles loading the cobalt ions. Through the blood vessels they accumulate in tumor regions rapidly. Meanwhile, they target the mitochondria and induce a reactive oxygen species storm, which eventually results in apoptosis of cancer cells.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Machine Learning in Bioinformatics · Cancer Research and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Synthetic and Functional Biomolecules Center Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of Chemistry and Molecular Engineering Innovation Center for Genomics Peking University Beijing 100871 China

State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine China Agricultural University Beijing 100094 China

Department of Radiology Clinical College of 307th Hospital of PLA Anhui Medical University 307 Hospital PLA Beijing 100071 China

Beijing Institute of Pharmacology and Toxicology National Beijing Center for Drug Safety Evaluation and Research State Key Laboratory of Toxicology and Medical Countermeasures Academy of Military Medical Sciences Beijing 100850 China

References

Reference metadata was not supplied for this record.