Tumor Visualization: Branched Gold Nanoparticle Coating of Clostridium novyi‐NT Spores for CT‐Guided Intratumoral Injection (Small 5/2017)
Source abstract
Abstract
Anaerobic Clostridium novyi-NT (C. novyi-NT) has proved to be effective for treating tumors. X-ray computed tomography (CT) image guided delivery of this strain of bacteria to tumors has several great advantages over previous methods. In article number 1602722, A. C. Larson, D.-H. Kim, and co-workers developed an approach to coat the surface of C. novyi-NT spores with gold nanoparticles for CT-guided bacteriolytic therapy. Branched gold nanoparticles-coated spores are successfully injected into a tumor site under CT image guidance. A strong anti-tumor effect was observed in the in vivo tumor model.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Infective Endocarditis Diagnosis and Management · Botulinum Toxin and Related Neurological Disorders · Orthopedic Infections and Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Radiology Feinberg School of Medicine Northwestern University Chicago IL 60611 USA
Robert H. Lurie Comprehensive Cancer Center Chicago IL 60611 USA
Department of Biomedical Engineering Northwestern University Evanston IL 60208 USA
Department of Electrical Engineering and Computer Science Northwestern University Evanston IL 60208 USA
International Institute of Nanotechnology (IIN) Northwestern University Evanston IL 60208 USA
References
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