Cancer Cells: Unleashing Cancer Cells on Surfaces Exposing Motogenic IGDQ Peptides (Small 3/2016)

On page 321, D. Bonifazi and co-workers report the motility of model breast cancer cells seeded onto surfaces exposing concentration gradients of the isoleucine-glycine-aspartate (IGD) motif. The peculiar migratory behavior is depicted in the image, where the long-distance displacement of a sub-population of cancer cells is observed along the verse imposed by the self-assembled gradient monolayer. These surfaces are proposed as platforms for the assessment of biochemical triggers influencing cancer cell migration and for the isolation of phenotypes fingerprinting a particular invasive behavior.