Biomaterials: Multifunctional Transmembrane Protein Ligands for Cell-Specific Targeting of Plasma Membrane-Derived Vesicles (Small 28/2016)

Cell-derived plasma membrane vesicles extracted from genetically engineered donor cells can selectively target cells based on their receptor expression profiles, as demonstrated by J. C. Stachowiak and co-workers on page 3837. These engineered donor cells have a stable expression of transmembrane protein ligands that contain multiple domains, including a targeting ligand, a spacer and a fluorophore.