Intracellular Delivery: Redox‐Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap‐Tops Enhances Efficacy Against Pneumonic Tularemia in Mice (Small 27/2016)
Source abstract
Abstract
The drug trapping and intracellular release mechanism of redox-responsive disulfide snap-top mesoporous silica nanoparticles (MSN-SS-MXF) is depicted by J. I. Zink, M. A. Horwitz and co-workers on page 3690. Mesoporous silica nanoparticles with antibiotic (cyan) trapped within their pores by disulfide snap-tops are avidly ingested by macrophages. The intracellular redox potential reduces the disulfide (yellow) in the stalk (green/blue), releases the caps (orange) and frees drug to kill Francisella tularensis (green). Artwork by Bastian Ruehle.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Bacillus and Francisella bacterial research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Division of Infectious Diseases Department of Medicine University of California CHS 37‐121, 10833 Le Conte Ave Los Angeles CA 90095‐1688 USA
Department of Chemistry and Biochemistry University of California 3013 Young Dr. East Los Angeles CA 90095–1569 USA
Department of Materials Science and Engineering University of California Los Angeles CA 90095 USA
California NanoSystems Institute University of California Los Angeles CA 90095–8352 USA
References
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