DataVXSmallPaper
journal article·2016-05Open access

Cell Phenotyping: Multiparametric Biomechanical and Biochemical Phenotypic Profiling of Single Cancer Cells Using an Elasticity Microcytometer (Small 17/2016)

Shuhuan Hu, Guangyu Liu, Weiqiang Chen, Xiang Li, Wei Lu, Raymond H. W. Lam, Jianping Fu

Small· Volume 12· Issue 17
Publisher pageOpen full text
Source abstract

Abstract

An elasticity microcytometer capable of multiparametric biomechanical and biochemical phenotypic profiling of single cancer cells is developed to interpret cell deformation along antibody-coated confining microchannels as quantitative cell characteristics including cell size, cell deformability/stiffness, and expression levels of surface receptors simultaneously for the same single live cancer cells. This elasticity microcytometer, developed by R. H. W. Lam, J. Fu and co-workers on page 2300, holds a great promise for comprehensive molecular, cellular, and biomechanical phenotypic profiling of live cancer cells at the single cell level.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Advanced Biosensing Techniques and Applications · Cellular Mechanics and Interactions · 3D Printing in Biomedical Research

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Affiliations

Department of Mechanical and Biomedical Engineering City University of Hong Kong 852 Hong Kong

Department of Mechanical Engineering University of Michigan Ann Arbor MI 48109 USA

Department of Mechanical and Aerospace Engineering New York University NY 11201 USA

City University of Hong Kong Shenzhen Research Institute Shenzhen 518057 China

Department of Biomedical Engineering University of Michigan Ann Arbor MI 48109 USA

Department of Cell and Developmental Biology University of Michigan Ann Arbor MI 48109 USA

Michigan Center for Integrative Research in Critical Care University of Michigan Ann Arbor MI 48109 USA

References

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