Imaging: Compact Halo‐Ligand‐Conjugated Quantum Dots for Multicolored Single‐Molecule Imaging of Overcrowding GPCR Proteins on Cell Membranes (Small 12/2015)
Source abstract
Abstract
In single-molecule fluorescence imaging, the optical resolution is restricted by the diffraction limit of light wavelength, which is approximately 200 nm when using visible light emission. M. Ueda, T. Jin, and co-workers show on page 1396 that the discrimination of individual GPCR proteins within the optical diffraction limit can be achieved by using multicolored single-molecule imaging with compact halo-ligand conjugated quantum dots. Three-colored single-molecule imaging enables increased detection of the GPCR proteins by a factor of 3 compared to one-colored single-molecule imaging.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · Monoclonal and Polyclonal Antibodies Research · Molecular Junctions and Nanostructures
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Affiliations
Laboratory for Nano‐Bio Probes Quantitative Biology Center, Riken Suita 565–0874 Osaka Japan
Laboratory for Cell Signaling Dynamics Quantitative Biology Center, Riken Suita 565–0874 Osaka Japan
Laboratory of Single Molecule Biology Department of Biological Sciences Graduate School of Science Osaka University Toyonaka 560–0043 Osaka Japan
References
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