Labeling: Small 2/2009

The cover page shows the use of polymer-coated metal nanoparticles as multiplexed nanoprobes based on surface-enhanced Raman scattering. Upon laser excitation, the nanoparticles of different synthetic origin emit characteristic Raman fingerprints, as reported by Hongyu Chen and co-workers on p. 198. The Au/Ag nanoparticles are surface functionalized with a layer of reporter molecules and then encapsulated by polystyrene-block-poly(acrylic acid). The polymer shell maintains the stability of the nanoprobes in adverse conditions while presenting identical surface groups. The nanoparticles' facile and reproducible synthesis shows potential for labeling applications.