Neuronal Networks: Assembly of Functional Three‐Dimensional Neuronal Networks on a Microchip (Small 13/2014)

A straightforward method to construct a structurally and functionally biomimetic 3D neuronal network on a microchip is presented on page 2530 by W. Zheng, X. Jiang, and co-workers, realizing highly ordered neuronal arrangement and guidance in structures and recordable neuronal activities simultaneously. Microchamber-assisted assembly of microspheres as scaffold supports the development of neuronal networks and microgrooves guide interconnections between networks. The structure shows spontaneous activities like those found in the brain. This approach shows promising applications in fundamental neuroscience, tissue engineering, and brain-machine interface.