Biomedical Imaging: Direct Solvent-Derived Polymer-Coated Nitrogen-Doped Carbon Nanodots with High Water Solubility for Targeted Fluorescence Imaging of Glioma (Small 29/2015)

Polymer-coated, nitrogen-doped, carbon nanodots (pN-CNDs), shown as green/blue particles in the image, are produced by R. Q. Huang and co-workers via a one-step direct solvothermal reaction of 1-methyl-2-pyrrolidinone. On page 3575, the pN-CNDs are shown to expediently enter glioma via blood vessels and mediate glioma fluorescence imaging in vivo with good contrast, via enhanced passive targeting.