Antiviral Agents: Correlation between Membrane Partitioning and Functional Activity in a Single Lipid Vesicle Assay Establishes Design Guidelines for Antiviral Peptides (Small 20/2015)
Source abstract
Abstract
A nanotechnology platform for highly parallel measurements is presented by N.-J. Cho and co-workers which monitors the interaction between membrane-active antiviral peptides and individual lipid vesicles. On page 2372, each vesicle is tethered to a passivated glass surface for highly specific detection. When the peptide forms a pore in the vesicle, fluorescent dye is released from inside the vesicle and the intensity change per vesicle can be followed in real time. Quantitative measurement capabilities enable comparison of various agents and are useful for drug development research.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · Lipid Membrane Structure and Behavior · Advanced Biosensing Techniques and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue 639798 Singapore
Centre for Biomimetic Sensor Science Nanyang Technological University 50 Nanyang Drive 637553 Singapore
School of Chemical and Biomedical Engineering Nanyang Technological University 62 Nanyang Drive 637459 Singapore
References
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