journal article·2020-10-27

Graphitic Carbon Nitride Quantum Dots Embedded in Carbon Nanosheets for Near-Infrared Imaging-Guided Combined Photo-Chemotherapy

Hongji Liu, Xiaotong Lv, Junchao Qian, Hong Li, Yong Qian, Xingyu Wang, Xiangfu Meng, Wenchu Lin, Hui Wang

ACS Nano· Volume 14· Issue 10
Publisher page

Abstract

Rational design of metal-free multifunctional therapeutic reagents offers great opportunities for cancer treatment in the clinic. Here, graphitic carbon nitride (g-C3N4) quantum dots embedded in carbon nanosheets (CNQD-CN) are in situ prepared via a one-pot hydrothermal approach with formamide as carbon and nitrogen source. The CNQD-CN not only serves as an excellent near-infrared (NIR) fluorescent marker but also acts as a pH-responsive nanocarrier. Moreover, the CNQD-CN possesses both light-to-heat conversion and singlet oxygen generation capabilities under a single NIR excitation wavelength. Further investigations show that systemic delivery of doxorubicin (DOX) using the multifunctional CNQD-CN nanocarrier under NIR irradiation was highly effective to cause cancer cell apoptosis in vitro and inhibit tumor growth in vivo. CNQD-CN represents a multifunctional therapeutic platform for synchronous cancer imaging and treatment through the synergistic effect of phototherapy and chemotherapy.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Carbon and Quantum Dots Applications · Nanoplatforms for cancer theranostics · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, People’s Republic of China

University of Science and Technology of China, Hefei 230026, Anhui, People’s Republic of China

Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University), Ministry of Education, Hefei 230601, Anhui, People’s Republic of China

Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, People’s Republic of China

Hefei Cancer Hospital, Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People’s Republic of China

Funding

National Natural Science Foundation of China · MOE Key Laboratory of Structure and Functional Regulation of Hybrid Materials, Anhui University · CAS Hefei Science Center

References (70)

Show source-provided references
1. 10.1038/s41568-019-0110-310.1038/s41568-019-0110-3 ↗
2. 10.1016/S1470-2045(18)30909-410.1016/S1470-2045(18)30909-4 ↗
3. 10.1039/C8CS00342D10.1039/C8CS00342D ↗
4. 10.1002/adma.20150630610.1002/adma.201506306 ↗
5. 10.1038/s41467-018-07947-810.1038/s41467-018-07947-8 ↗
6. 10.1002/adma.20130449710.1002/adma.201304497 ↗
7. 10.1002/adma.20150087010.1002/adma.201500870 ↗
8. 10.1002/adfm.20180732610.1002/adfm.201807326 ↗
9. 10.1016/j.tibtech.2018.05.01210.1016/j.tibtech.2018.05.012 ↗
10. 10.1002/adhm.20180052510.1002/adhm.201800525 ↗
11. 10.1073/pnas.171442111510.1073/pnas.1714421115 ↗
12. 10.1021/jacs.5b0602510.1021/jacs.5b06025 ↗
13. 10.1021/acsnano.6b0415610.1021/acsnano.6b04156 ↗
14. 10.1002/adma.20160327610.1002/adma.201603276 ↗
15. 10.1002/adfm.20180830610.1002/adfm.201808306 ↗
16. 10.1039/C8CS00823J10.1039/C8CS00823J ↗
17. 10.1021/acsami.7b1721910.1021/acsami.7b17219 ↗
18. 10.1002/adma.20180438610.1002/adma.201804386 ↗
19. 10.1021/acs.chemmater.7b0196510.1021/acs.chemmater.7b01965 ↗
20. 10.1002/adma.20180310110.1002/adma.201803101 ↗
21. 10.1016/j.mattod.2017.09.00110.1016/j.mattod.2017.09.001 ↗
22. 10.1039/C4CS00300D10.1039/C4CS00300D ↗
23. 10.1021/ja201017510.1021/ja2010175 ↗
24. 10.1016/j.apmt.2018.11.01110.1016/j.apmt.2018.11.011 ↗
25. 10.1016/j.biomaterials.2019.11970010.1016/j.biomaterials.2019.119700 ↗
26. 10.1039/C6CS00442C10.1039/C6CS00442C ↗
27. 10.1039/C4CS00269E10.1039/C4CS00269E ↗
28. 10.1021/acs.chemrev.9b0009910.1021/acs.chemrev.9b00099 ↗
29. 10.1021/acs.chemrev.6b0007310.1021/acs.chemrev.6b00073 ↗
30. 10.1039/C8NJ05740K10.1039/C8NJ05740K ↗
31. 10.1039/C9TB01410A10.1039/C9TB01410A ↗
32. 10.1002/ange.20151121710.1002/ange.201511217 ↗
33. 10.1002/adma.20140011110.1002/adma.201400111 ↗
34. 10.1039/C9NJ03081F10.1039/C9NJ03081F ↗
35. 10.1002/slct.20180249210.1002/slct.201802492 ↗
36. 10.1021/acsabm.9b0005510.1021/acsabm.9b00055 ↗
37. 10.1021/acsbiomaterials.7b0011010.1021/acsbiomaterials.7b00110 ↗
38. 10.1002/smll.20160205610.1002/smll.201602056 ↗
39. 10.1021/acscatal.8b0046710.1021/acscatal.8b00467 ↗
40. 10.1039/C4TA03128H10.1039/C4TA03128H ↗
41. 10.1039/c3cc45532g10.1039/c3cc45532g ↗
42. 10.1016/j.mattod.2018.06.00810.1016/j.mattod.2018.06.008 ↗
43. 10.1039/C8TC00191J10.1039/C8TC00191J ↗
44. 10.1038/nmat231710.1038/nmat2317 ↗
45. 10.1002/adma.20190354510.1002/adma.201903545 ↗
46. 10.1016/j.apcatb.2019.11786710.1016/j.apcatb.2019.117867 ↗
47. 10.1016/j.matlet.2011.01.00810.1016/j.matlet.2011.01.008 ↗
48. 10.1002/adma.20160141310.1002/adma.201601413 ↗
49. 10.1002/adma.20090206910.1002/adma.200902069 ↗
50. 10.1021/acs.nanolett.9b0112710.1021/acs.nanolett.9b01127 ↗
51. 10.1002/adfm.20190232210.1002/adfm.201902322 ↗
52. 10.1021/nn100883p10.1021/nn100883p ↗
53. 10.1016/j.jcis.2019.01.06710.1016/j.jcis.2019.01.067 ↗
54. 10.1021/ja512179x10.1021/ja512179x ↗
55. 10.1002/anie.20151094510.1002/anie.201510945 ↗
56. 10.1002/anie.20110665610.1002/anie.201106656 ↗
57. 10.1002/anie.20120533310.1002/anie.201205333 ↗
58. 10.1021/ac500516210.1021/ac5005162 ↗
59. 10.1021/acsami.5b0090810.1021/acsami.5b00908 ↗
60. 10.1021/am402207610.1021/am4022076 ↗
61. 10.1002/adma.20150032310.1002/adma.201500323 ↗
62. 10.1002/adma.20187028310.1002/adma.201870283 ↗
63. 10.1002/anie.20170365710.1002/anie.201703657 ↗
64. 10.1002/adma.20187026810.1002/adma.201870268 ↗
65. 10.1038/ncomms559610.1038/ncomms5596 ↗
66. 10.1002/adhm.20170127210.1002/adhm.201701272 ↗
67. 10.1021/acsami.8b0289010.1021/acsami.8b02890 ↗
68. 10.1002/adfm.20150152410.1002/adfm.201501524 ↗
69. 10.1039/C5CS00499C10.1039/C5CS00499C ↗
70. 10.1038/ncomms265510.1038/ncomms2655 ↗