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journal article·2020-06Open access

Angiogenesis: Mechanical Cues Regulating Proangiogenic Potential of Human Mesenchymal Stem Cells through YAP‐Mediated Mechanosensing (Small 25/2020)

Praveen Bandaru, Giorgia Cefaloni, Fereshteh Vajhadin, KangJu Lee, Han‐Jun Kim, Hyun‐Jong Cho, Martin C. Hartel, Shiming Zhang, Wujin Sun, Marcus J. Goudie, Samad Ahadian, Mehmet Remzi Dokmeci, Junmin Lee, Ali Khademhosseini

Small· Volume 16· Issue 25
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Source abstract

Abstract

In article number 2001837, Junmin Lee, Ali Khademhosseini, and co-workers develop a bioreactor-based platform to investigate the effect of human mesenchymal stem cell (hMSC) culture microenvironments including matrix rigidity and dynamic mechanical compression on their secretion level of pro-angiogenic factors. It is demonstrated that these mechanical cues regulate pro-angiogenic potential of hMSCs through yes-associated protein (YAP)-mediated mechanosensing.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Mesenchymal stem cell research · Hippo pathway signaling and YAP/TAZ · Periodontal Regeneration and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Bioengineering Henry Samueli School of Engineering and Applied Sciences University of California, Los Angeles Los Angeles CA 90095 USA

Center for Minimally Invasive Therapeutics (C‐MIT) University of California, Los Angeles Los Angeles CA 90095 USA

Department of Chemistry Faculty of Science Yazd University Yazd 89195‐741 Iran

College of Pharmacy Kangwon National University Chuncheon Gangwon 24341 Republic of Korea

Terasaki Institute for Biomedical Innovation Los Angeles CA 90064 USA

Department of Radiology David Geffen School of Medicine University of California, Los Angeles Los Angeles CA 90095 USA

Department of Chemical and Biomolecular Engineering Henry Samueli School of Engineering and Applied Sciences University of California, Los Angeles Los Angeles CA 90095 USA

References

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