Metal‐Based Nanoparticles: Mechanistic Differences in Cell Death Responses to Metal‐Based Engineered Nanomaterials in Kupffer Cells and Hepatocytes (Small 21/2020)

In article number 2000528, André E. Nel, Tian Xia, and co-workers show how metal-based nanoparticles are taken up by liver cells including Kupffer cells and hepatocytes, where they induce tiered oxidative stress responses including mitochondrial reactive oxygen species generation, glutathione depletion, expression of phase II enzymes such as HO-1, production of pro-inflammatory cytokines including IL-1β and TNF-α, and cell death via different mechanisms including apoptosis (Ag, CuO, ZnO, V2O5) and pyroptosis (fumed SiO2).