Microcirculation‐on‐Chip: Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution (Small 46/2019)
Source abstract
Abstract
In article number 1902393, Charles G. Knutson, Roger D. Kamm, and co-workers use microvascular networks self-assembled from human cells within microfluid devices to directly measure trans-capillary solute flux. Physiological fluid flow through the cell junctions, passive diffusion across the cell membrane, and active vesicular transport, recapitulate the in vivo mode and magnitude of transport for different types of therapeutic molecules.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: 3D Printing in Biomedical Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biological Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA
LaBS Department of Chemistry Materials and Chemical Engineering Politecnico di Milano Milan 20133 Italy
BIOS Lab‐on‐a‐Chip Group University of Twente Enschede 7522 The Netherlands
MOX Department of Mathematics Politecnico di Milano Milan 20133 Italy
Amgen Discovery Research Amgen Inc., 360 Binney Street Cambridge MA 02141 USA
References
Reference metadata was not supplied for this record.