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journal article·2024-05Open access

Synergistic Effect of Ferroptosis‐Inducing Nanoparticles and X‐Ray Irradiation Combination Therapy (Small 19/2024)

Chaewon Bae, Rodrigo Hernández Millares, Suhyun Ryu, Hyowon Moon, Dongwoo Kim, Gyubok Lee, Zhuomin Jiang, Min Hee Park, Kyung Hwan Kim, Woong Sub Koom, Sung‐Joon Ye, Kangwon Lee

Small· Volume 20· Issue 19
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Source abstract

Abstract

Cancer Nanomedicine In article number 2310873, Woong Sub Koom, Sung-Joon Ye, Kangwon Lee, and co-workers report the strategy and efficacy of tumor combination treatment with X-ray irradiation and the developed FHA-nanoparticles that induce ferroptosis. Effective tumor synergistic treatment effects were confirmed, and Monte Carlo simulations were performed to evaluate the physical interactions. This platform identifies the role of ferroptosis in X-ray therapy and provides insights into clarifying the correlation and role of radiation and ferroptosis for effective cancer treatment.
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Research context

Nanomaterials

OpenAlex topics: Ferroptosis and cancer prognosis

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Affiliations

Program in Nanoscience and Technology Graduate School of Convergence Science and Technology Seoul National University Seoul 08826 Republic of Korea

Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Seoul 08826 Republic of Korea

Department of Applied Bioengineering Graduate School of Convergence Science and Technology Seoul National University Seoul 08826 Republic of Korea

Department of Radiation Oncology Yonsei Cancer Center Heavy Ion Therapy Research Institute Yonsei University College of Medicine Seoul 03722 Republic of Korea

THEDONEE 1208, 156, Gwanggyo‐ro, Yeongtong‐gu Suwon‐si Gyeonggi‐do 16506 Republic of Korea

Biomedical Research Institute Seoul National University Hospital Seoul 03080 South Korea

Advanced Institute of Convergence Technology Seoul National University Suwon 16229 South Korea

Research Institute for Convergence Science Seoul National University Seoul 08826 Republic of Korea

References

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