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journal article·2024-04Open access

Cold to Hot: Tumor Immunotherapy by Promoting Vascular Normalization Based on PDGFB Nanocomposites (Small 16/2024)

Shouzheng Ma, Zhimin Tian, Lei Liu, Jun Zhu, Jing Wang, Shoujie Zhao, Yejing Zhu, Jianfei Zhu, Wenchen Wang, Runmin Jiang, Yongquan Qu, Jie Lei, Junlong Zhao, Tao Jiang

Small· Volume 20· Issue 16
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Source abstract

Abstract

Tumor Immunotherapy Tumor vascular abnormalities is a profound determinant in the “cold” tumor immune microenvironment establishment by hindering immunotherapy efficacy. PDGFB@ZIF8-RGD effectively induced tumor vascular normalization, by reprogramming the “cold” TIME to a “hot” tumor immune microenvironment and facilitated robust antitumor immunity. More in article number 2308638, Yongquan Qu, Jie Lei, Junlong Zhao, Tao Jiang, and co-workers.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Immune cells in cancer · Cancer Immunotherapy and Biomarkers

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Thoracic Surgery Tangdu Hospital Air Force Medical University Xi'an 710038 China

Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology School of Chemistry and Chemical Engineering Northwestern Polytechnical University Xi'an 710072 China

State Key Laboratory of Cancer Biology and National Clinical Research Center for Digestive Diseases Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an Shaanxi Province 710032 China

The Southern Theater Air Force Hospital Guangzhou 510000 China

Department of Immunology Air Force Medical University Xi'an 710032 China

Department of General Surgery Tangdu Hospital Air Force Medical University Xi'an 710038 China

Department of Thoracic Surgery Shaanxi Provincial People's Hospital Xi'an 710068 China

State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Medical Genetics and Development Biology Air Force Medical University Xi'an 710032 China

Department of Pediatrics Tangdu Hospital Air Force Medical University Xi'an 710000 China

References

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