Enhanced Mitochondrial Targeting and Inhibition of Pyroptosis with Multifunctional Metallopolyphenol Nanoparticles in Intervertebral Disc Degeneration (Small 13/2024)

Hao Zhou; Qiuping Qian; Qizhu Chen; Tao Chen; Chenyu Wu; Linjie Chen; Zhiguang Zhang; Ouqiang Wu; Yuxin Jin; Xinzhou Wang; Zhenyu Guo; Jing Sun; Jun Zhang; Shuying Shen; Xiangyang Wang; Morgan Jones; Moonis Ali Khan; Pooyan Makvandi; Yunlong Zhou; Aimin Wu

doi:10.1002/smll.202470102

journal article·2024-03Open access

Enhanced Mitochondrial Targeting and Inhibition of Pyroptosis with Multifunctional Metallopolyphenol Nanoparticles in Intervertebral Disc Degeneration (Small 13/2024)

Hao Zhou, Qiuping Qian, Qizhu Chen, Tao Chen, Chenyu Wu, Linjie Chen, Zhiguang Zhang, Ouqiang Wu, Yuxin Jin, Xinzhou Wang, Zhenyu Guo, Jing Sun, Jun Zhang, Shuying Shen, Xiangyang Wang, Morgan Jones, Moonis Ali Khan, Pooyan Makvandi, Yunlong Zhou, Aimin Wu

Small· Volume 20· Issue 13

Publisher page Open full text

Source abstract

Abstract

Intervertebral Disc Degeneration In article number 2308167, Pooyan Makvandi, Yunlong Zhou, Aimin Wu, and co-workers prepared a multifunctional metal polyphenol nanoparticle that exhibited the ability to escape lysosomal capture and effectively targeted mitochondria to scavenge excess reactive oxygen species. The results of in vitro and in vivo experiments showed that the nanoparticles retarded disc degeneration by inhibiting Pyroptosis and maintaining the metabolic homeostasis of the extracellular matrix in the nucleus pulposus.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Spine and Intervertebral Disc Pathology · Healthcare and Venom Research · Musculoskeletal pain and rehabilitation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopaedics Key Laboratory of Structural Malformations in Children of Zhejiang Province Key Laboratory of Orthopaedics of Zhejiang Province The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou Zhejiang 325000 China

Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou Institute University of Chinese Academy of Sciences Wenzhou Zhejiang 325000 China

Department of Orthopaedics, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Tongji Hospital Tongji University School of Medicine, School of Life Science and<?brk?> Technology Tongji University Shanghai 200065 China<?vsp 5pt?>

Zhejiang Provincial People's Hospital Bijie Hospital Bijie Guizhou 551700 China

Department of Orthopaedics Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province Sir Run Shaw Hospital Zhejiang University School of Medicine Hangzhou 310000 China

Spine Unit The Royal Orthopaedic Hospital Bristol Road South, Northfield Birmingham B31 2AP United Kingdom

Chemistry Department College of Science King Saud University Riyadh 11451 Saudi Arabia

The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People's Hospital Quzhou Zhejiang 324000 China

References

Reference metadata was not supplied for this record.