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journal article·2024-03Open access

Multi‐Omics Reveals the Genetic and Metabolomic Architecture of Chirality Directed Stem Cell Lineage Diversification (Small 10/2024)

Huimin Zheng, Shengjie Jiang, Meijun Li, Jinying Liu, Xiaowei Wang, Minghua Liu, Chuanliang Feng, Yan Wei, Xuliang Deng

Small· Volume 20· Issue 10
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Source abstract

Abstract

Chirality-Guided Diversification High-throughput transcriptional-metabolic pipeline profiling and network analysis characterized gene-expression and chemical-variation landscape of chirality-guided lineage diversification. In article number 2306400, Minghua Liu, Chuanliang Feng, Yan Wei, Xuliang Deng, and co-workers found chirality-ordered transcriptomic-metabolic regulatory networks, emphasizing positive feedback loops between key genes and central metabolites driving diversification. A comprehensive understanding of molecular architecture in chirality-guided diversification informs functionalized material design in medicine and chemistry.
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Research context

OpenAlex topics: 3D Printing in Biomedical Research

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Affiliations

Beijing Laboratory of Biomedical Materials Department of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing 100081 P. R. China

Institute of Medical Technology Peking University Health Science Center Beijing 100191 P. R. China

Beijing National Laboratory for Molecular Science CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China

University of Chinese Academy of Sciences Beijing 100049 P. R. China

Key Laboratory for Special Functional Materials of Ministry of Education, School of Materials Science and Engineering Henan University Kaifeng 475004 P. R. China

State Key Laboratory of Metal Matrix Composite School of Materials and Science Technology Shanghai Jiaotong University Shanghai 200240 P. R. China

References

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