Reconstituted Extracellular Vesicles from Human Platelets Decrease Viral Myocarditis in Mice (Small 49/2023)

Danielle J. Beetler; Katelyn A. Bruno; Molly M. Watkins; Vivian Xu; Isha Chekuri; Presley Giresi; Damian N. Di Florio; Emily R. Whelan; Brandy H. Edenfield; Sierra A. Walker; Andrea C. Morales‐Lara; Anneliese R. Hill; Angita Jain; Matthew E. Auda; Logan P. Macomb; Kathryn A. Shapiro; Kevin C. Keegan; Joy Wolfram; Atta Behfar; Paul G. Stalboerger; Andre Terzic; Houssam Farres; Leslie T. Cooper; DeLisa Fairweather

doi:10.1002/smll.202370414

journal article·2023-12Open access

Reconstituted Extracellular Vesicles from Human Platelets Decrease Viral Myocarditis in Mice (Small 49/2023)

Danielle J. Beetler, Katelyn A. Bruno, Molly M. Watkins, Vivian Xu, Isha Chekuri, Presley Giresi, Damian N. Di Florio, Emily R. Whelan, Brandy H. Edenfield, Sierra A. Walker, Andrea C. Morales‐Lara, Anneliese R. Hill, Angita Jain, Matthew E. Auda, Logan P. Macomb, Kathryn A. Shapiro, Kevin C. Keegan, Joy Wolfram, Atta Behfar, Paul G. Stalboerger, Andre Terzic, Houssam Farres, Leslie T. Cooper, DeLisa Fairweather

Small· Volume 19· Issue 49

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Source abstract

Abstract

Regenerative Medicine Extracellular vesicles from healthy human platelets globally control inflammation in the hearts of mice with viral myocarditis by regulating the innate immune response with their heterogenous functional contents. This immunomodulation in part comes from anti-inflammatory microRNAs and prevents cardiac dysfunction during peak acute myocarditis. The therapeutic tested in article number 2303317 by DeLisa Fairweather and co-workers offers a novel and translatable option for inflammatory cardiovascular diseases.

Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Center for Clinical and Translational Science Mayo Clinic Rochester MN 55902 USA

Department of Cardiovascular Medicine Mayo Clinic Jacksonville FL 32224 USA

Mayo Clinic Graduate School of Biomedical Sciences Mayo Clinic Rochester MN 55902 USA

Division of Cardiovascular Medicine University of Florida Gainesville FL 32608 USA <?vsp -10pt?>

Department of Cancer Biology Mayo Clinic Jacksonville FL 32224 USA

Department of Biochemistry and Molecular Biology Rochester MN 55902 USA

School of Chemical Engineering Australian Institute for Bioengineering and Nanotechnology The University of Queensland Brisbane QLD 4072 Australia

Department of Molecular Pharmacology & Experimental Therapeutics Mayo Clinic Rochester MN 55905 USA

Van Cleve Cardiac Regenerative Medicine Program Mayo Clinic Center for Regenerative Medicine Rochester MN 55905 USA

Department of Clinical Genomics Mayo Clinic Rochester MN 55905 USA

Department of Vascular Surgery Mayo Clinic Jacksonville FL 32224 USA

Department of Immunology Mayo Clinic Jacksonville FL 32224 USA <?vsp -20pt?>

References

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