Recruitment of Receptors and Ligands in a Weakly Multivalent System with Omnipresent Signatures of Superselective Binding (Small 23/2023)

Receptor Recruitment Ligand-functionalized lipid vesicles bind to receptor-functionalized supported lipid bilayers through weak, multivalent receptor-ligand interactions. As a result of binding, surface-bound receptors move into the area of contact – a process called “recruitment” – to increase the local receptor density and thus enhance binding. The affinity, the size and the receptor density of the contact area, all show characteristic non-linear trends. More details can be found in article number 2206596 by Jurriaan Huskens and co-workers.