DataVXSmallPaper
journal article·2023-02Open access

One‐Pot Controllable Assembly of a Baicalin‐Condensed Aptamer Nanodrug for Synergistic Anti‐Obesity (Small 6/2023)

Jingjing Tian, Xiaoyun He, Xinyue Lan, Xingxing Liang, Zhaobin Zhong, Longjiao Zhu, Keren Chen, Qiaoying Chang, Wentao Xu

Small· Volume 19· Issue 6
Publisher pageOpen full text
Source abstract

Abstract

Baicalin-Condensed Aptamer Nanodrugs Polymerase chain reaction (PCR)-driven DNA micro-nano-flowers are used to construct a nanosized baicalin-compressed-aptamer-nanodrug (bcaND) via one-pot assembly. The tailored Adipo-8 (tAdi-8) overhang in the PCR amplicon, like an arrow, displays anti-obesity targeting activity, while the baicalin loaded in the bcaND plays a three-fold role as a lipid-lowering factor, bcaND size compressor, and uncoupling protein-1 (UCP1)-raised thermogenic activator. More details can be found in article number 2205933 by Wentao Xu and co-workers.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Food Laboratory of Zhongyuan Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University Beijing 100083 China

Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety) (MOA) College of Food Science and Nutritional Engineering China Agricultural University Beijing 100083 China

Key Laboratory of Food Processing and Quality Control College of Food Science and Technology Nanjing Agricultural University Nanjing 210095 China

References

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