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journal article·2023-02Open access

High‐Throughput Cellular Heterogeneity Analysis in Cell Migration at the Single‐Cell Level (Small 6/2023)

Mengli Zhou, Yushu Ma, Chun‐Cheng Chianga, Edwin C. Rock, Kathryn E. Luker, Gary D. Luker, Yu‐Chih Chen

Small· Volume 19· Issue 6
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Source abstract

Abstract

High-Throughput Cellular Heterogeneity In article number 2206754, Yu-Chih Chen and co-workers present a microfluidic cell migration platform that coordinates robotic liquid handling and computer vision for rapidly quantifying individual cellular motility. The high-throughput single-cell screening experiments reveal that many compounds inhibit migration of most cells while leaving fast-moving subpopulations unaffected. They further investigate dynamic cell movement and discover synergistic drug combinations that overcome the resistance of fast-moving subpopulations.
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Research context

OpenAlex topics: 3D Printing in Biomedical Research · Innovative Microfluidic and Catalytic Techniques Innovation

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Affiliations

UPMC Hillman Cancer Center University of Pittsburgh 5115 Centre Ave Pittsburgh PA 15232 USA

Department of Computational and Systems Biology University of Pittsburgh 3420 Forbes Avenue Pittsburgh PA 15260 USA

Xiangya Hospital Central South University Changsha Hunan 410008 China

Department of Bioengineering Swanson School of Engineering University of Pittsburgh 3700 O'Hara Street Pittsburgh PA 15260 USA

Center for Molecular Imaging Department of Radiology University of Michigan 109 Zina Pitcher Place Ann Arbor MI 48109‐2200 USA

Department of Microbiology and Immunology University of Michigan 109 Zina Pitcher Place Ann Arbor MI 48109‐2200 USA

Department of Biomedical Engineering University of Michigan 2200 Bonisteel, Blvd Ann Arbor MI 48109‐2099 USA

CMU‐Pitt Ph.D. Program in Computational Biology University of Pittsburgh 3420 Forbes Avenue Pittsburgh PA 15260 USA

References

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