Nanoengineered Granular Hydrogel Bioinks with Preserved Interconnected Microporosity for Extrusion Bioprinting (Small 37/2022)

Extrusion Bioprinting In article number 2202390, Amir Sheikhi and co-workers develop a nanoengineered granular bioink (NGB) to enable the extrusion 3D bioprinting of hydrogel microparticle (microgel)–based scaffolds with preserved interconnected microporosity. The reversible self-assembly of heterogeneously charged colloidal nanoplatelets adsorbed onto gelatin methacryloyl microgels enable the extrudability and shape fidelity of NGB at a low packing state without filling the void spaces among the microgels. This work opens new opportunities for the 3D bioprinting of tissue engineered microporous scaffolds beyond the traditional biofabrication window.