Penetrating Micelle for Reversing Immunosuppression and Drug Resistance in Pancreatic Cancer Treatment (Small 18/2022)
Source abstract
Abstract
Pancreatic Cancer Treatment In article number 2107712, Tao Sun, Chen Jiang, and co-workers develop a versatile drug delivery system that can co-encapsulate two hypoxia-responsive prodrugs modified from gemcitabine and a STAT3 inhibitor. The system can respond to the gradient pH variation in the tumor microenvironment to realize higher penetration by reversing its surficial charges, with the aim of simultaneously reversing immunosuppression and drug resistance in pancreatic cancer treatment.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Immune cells in cancer · Cancer Research and Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Smart Drug Delivery (Ministry of Education) Minhang Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Research Center on Aging and Medicine Fudan University Shanghai 201203 P. R. China
Department of Interventional Radiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 P. R. China
References
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