Gene Silencing: Therapeutic Gene Silencing Using Targeted Lipid Nanoparticles in Metastatic Ovarian Cancer (Small 19/2021)
Source abstract
Abstract
Lipid nanoparticles encapsulating two different small interfering ribonucleic acids are developed that block essential pathways for cancer cell survival. Targeting of metastasized ovarian cancer cells is further enhanced by coating nanoparticles with hyaluronan. Robust gene silencing in key tissues involved in ovarian cancer pathophysiology in an advanced ovarian cancer mouse model and improved median and overall survival are demonstrated by Dan Peer and co-workers in article number 2100287.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Cancer Research and Treatments
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Affiliations
Laboratory of Precision NanoMedicine Tel Aviv University Tel Aviv 69978 Israel
School of Molecular Cell Biology & Biotechnology George S. Wise Faculty of Life Sciences Tel Aviv University Tel Aviv 69978 Israel
Department of Materials Sciences & Engineering Iby and Aladar Fleischman Faculty of Engineering Tel Aviv University Tel Aviv 69978 Israel
Center for Nanoscience and Nanotechnology Tel Aviv University Tel Aviv 69978 Israel
Cancer Biology Research Center Tel Aviv University Tel Aviv 69978 Israel
References
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