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journal article·2021-04Open access

Organ‐on‐a‐Chip: A Heart‐Breast Cancer‐on‐a‐Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy (Small 15/2021)

Junmin Lee, Shreya Mehrotra, Elaheh Zare‐Eelanjegh, Raquel O. Rodrigues, Alireza Akbarinejad, David Ge, Luca Amato, Kiavash Kiaee, YongCong Fang, Aliza Rosenkranz, Wendy Keung, Biman B. Mandal, Ronald A. Li, Ting Zhang, HeaYeon Lee, Mehmet Remzi Dokmeci, Yu Shrike Zhang, Ali Khademhosseini, Su Ryon Shin

Small· Volume 17· Issue 15
Publisher pageOpen full text
Source abstract

Abstract

In article number 2004258, Ali Khademhosseini, Su Ryon Shin, and co-workers develop a model for investigating chemotherapy-induced cardiotoxicity where induced pluripotent stem cell-derived cardiac tissues are interacted with breast cancer tissues on a dual-organ platform. Using electrochemical immuno-aptasensors to monitor cell-secreted multiple biomarkers, the proposed platform could be potentially suitable for early detection and prediction of cardiotoxicity in individual patients.
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Research context

OpenAlex topics: 3D Printing in Biomedical Research

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Affiliations

Division of Engineering in Medicine Brigham and Women's Hospital Department of Medicine Harvard Medical School Cambridge MA 02139 USA

Harvard‐MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge MA 02139 USA

Department of Bioengineering Henry Samueli School of Engineering and Applied Sciences University of California, Los Angeles Los Angeles CA 90095 USA

Center for Minimally Invasive Therapeutics (C‐MIT) University of California, Los Angeles Los Angeles CA 90095 USA

Terasaki Institute for Biomedical Innovation Los Angeles CA 90064 USA

Department of Biosciences and Bioengineering Indian Institute of Technology Guwahati Guwahati Assam 781039 India

Center for MicroElectromechanical Systems (CMEMS‐UMinho) University of Minho Campus de Azurém Guimarães 4800‐058 Portugal

Department of Chemistry Faculty of Basic Sciences Tarbiat Modares University Tehran 14115‐175 Iran

Department of Mechanical Engineering Stevens Institute of Technology Hoboken NJ 07030 USA

Department of Mechanical Engineering Tsinghua University Beijing 100084 China

Dr. Li Dak Sum Research Centre The University of Hong Kong Pokfulam Hong Kong

Centre for Nanotechnology Indian Institute of Technology Guwahati Guwahati Assam 781039 India

Department of Paediatrics and Adolescent Medicine LKS Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong

Ming Wai Lau Centre for Reparative Medicine Karolinska Institutet Shatin Hong Kong

MARA Nanotech New York, inc. New York NY 10031‐9101 USA

Department of Radiology David Geffen School of Medicine University of California, Los Angeles Los Angeles CA 90095 USA

References

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