journal article·2021-03Open access

Antibiotic Resistance: Microfluidic Evolution‐On‐A‐Chip Reveals New Mutations that Cause Antibiotic Resistance (Small 10/2021)

Ahmed E. Zoheir, Georg P. Späth, Christof M. Niemeyer, Kersten S. Rabe

Small· Volume 17· Issue 10

Abstract

Microfluidics reveals ambiguous antibiotic resistance scenarios. A custom microfluidic device reported by Kersten S. Rabe and co-workers (article number 2007166) elucidates for the first time how bacteria turn into either resistant or persistent “superbugs” due to varying antibiotic exposure. The chip accelerates evolution, leading to the discovery of previously unknown resistance mutations within hours, paving the way for a better understanding of the mechanisms of resistance.
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Research context

OpenAlex topics: Innovative Microfluidic and Catalytic Techniques Innovation · Antibiotic Use and Resistance

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Affiliations

Institute for Biological Interfaces 1 (IBG‐1) Karlsruhe Institute of Technology (KIT) Hermann‐von‐Helmholtz‐Platz 1 Eggenstein‐Leopoldshafen 76344 Germany

Department of Genetics and Cytology National Research Centre (NRC) 33 El Buhouth St. Cairo 12622 Egypt

References

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