journal article·2019-04Open access

DNA Sensors: Transducing Protease Activity into DNA Output for Developing Smart Bionanosensors (Small 14/2019)

Hieu Bui, Carl W. Brown, Susan Buckhout‐White, Sebastián A. Díaz, Michael H. Stewart, Kimihiro Susumu, Eunkeu Oh, Mario G. Ancona, Ellen R. Goldman, Igor L. Medintz

Small· Volume 15· Issue 14

Abstract

In article number 1805384, Igor L. Medintz and co-workers evaluate a protease to DNA output sensor. Peptide-DNAs are assembled onto quantum dots as the input gate. Proteases cleave the peptide altering Förster resonance energy transfer efficiency with the quantum dot, freeing a DNA output to interact with a tetrahedral output gate. Converting sensor output to DNA sequences allows for information processing by DNA computation. Artistic rendition by Ella Maru.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques

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Affiliations

Center for Bio/Molecular Science and Engineering Code 6900 U.S. Naval Research Laboratory Washington DC 20375 USA

National Research Council 500 Fifth Street NW, Keck 576 Washington DC 20001 USA

College of Science George Mason University Fairfax VA 22030 USA

Optical Sciences Division Code 5611 U.S. Naval Research Laboratory Washington DC 20375 USA

KeyW Corporation Hanover MD 21076 USA

Electronic Science and Technology Division Code 6800 U.S. Naval Research Laboratory Washington DC 20375 USA

References

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