DataVXSmallPaper
journal article·2018-06Open access

Oxidative Stress Imaging: Visualizing Oxidative Cellular Stress Induced by Nanoparticles in the Subcytotoxic Range Using Fluorescence Lifetime Imaging (Small 23/2018)

Jens Balke, Pierre Volz, Falko Neumann, Robert Brodwolf, Alexander Wolf, Hannah Pischon, Moritz Radbruch, Lars Mundhenk, Achim D. Gruber, Nan Ma, Ulrike Alexiev

Small· Volume 14· Issue 23
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Source abstract

Abstract

In article number 1800310, Nan Ma, Ulrike Alexiev, and co-workers develop a sensitive and reproducible fluorescence lifetime based imaging assay (FLIM-ROX) for reactive oxygen species (ROS) detection that allows the investigation of low cellular stress levels as a consequence of ROS production. Using FLIM-ROX, the nanotoxicity of subcytotoxic amounts of nanoparticles is demonstrated by linking cellular adverse effects, such as cellular morphology changes, elevated senescence, and DNA damage, to low-level oxidative stress.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoparticles: synthesis and applications · Optical Imaging and Spectroscopy Techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Physics Freie Universität Berlin Arnimalllee 14 14195 Berlin Germany

Institute of Chemistry and Biochemistry Freie Universität Berlin Takustraße 3 14195 Berlin Germany

Helmholtz Virtual Institute—Multifunctional Biomaterials for Medicine Helmholtz‐Zentrum Geesthacht Kantstr. 55 14513 Teltow Germany

Institute of Veterinary Pathology Freie Universität Berlin Robert‐von‐Ostertagstraße 15 14163 Berlin Germany

Helmholtz‐Zentrum Geesthacht (HZG) Institut für Biomaterialforschung Kantstr. 55 14513 Teltow Germany

References

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