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journal article·2017-10Open access

Peptides: Rational Design of Membrane‐Pore‐Forming Peptides (Small 40/2017)

Max Pillong, Jan A. Hiss, Petra Schneider, Yen‐Chu Lin, Gernot Posselt, Bernhard Pfeiffer, Markus Blatter, Alex T. Müller, Simon Bachler, Claudia S. Neuhaus, Petra S. Dittrich, Karl‐Heinz Altmann, Silja Wessler, Gisbert Schneider

Small· Volume 13· Issue 40
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Source abstract

Abstract

In article number 1701316, by Gisbert Schneider and co-workers, a novel peptide descriptor enables the rational design of peptides based on their topological hydrophobic distribution. Applying this descriptor, a computational method generates an innovative peptide inspired by a natural template. This peptide is then trialed and optimized for its ability to disrupt bacterial cells by forming ordered, pore-like structures in membranes in an entropy-driven mechanism.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Antimicrobial Peptides and Activities · Chemical Synthesis and Analysis · Supramolecular Self-Assembly in Materials

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Affiliations

Department of Chemistry and Applied Biosciences ETH Zurich 8093 Zurich Switzerland

Department of Molecular Biology University of Salzburg 5020 Salzburg Austria

Department of Biosystems Science and Engineering ETH Zurich 8093 Zurich Switzerland

References

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