DataVXSmallPaper
journal article·2017-09Open access

Thermoplasmonics: Molecular Hyperthermia: Spatiotemporal Protein Unfolding and Inactivation by Nanosecond Plasmonic Heating (Small 36/2017)

Peiyuan Kang, Zhuo Chen, Steven O. Nielsen, Kenneth Hoyt, Sheena D'Arcy, Jeremiah J. Gassensmith, Zhenpeng Qin

Small· Volume 13· Issue 36
Publisher pageOpen full text
Source abstract

Abstract

In article number 1700841, Zhenpeng Qin and co-workers develop a novel method to create highly specific therapies by inactivating dysfunctional protein molecules. The approach inactivates protein molecules of interest by using short laser pulses and nanoparticles. This is achieved by nanosecond plasmonic heating of gold nanoparticles which creates an ultrahigh and ultrashort temperature increase, leading to selective inactivation and unfolding of proteins adjacent to the nanoparticle.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Toxin Mechanisms and Immunotoxins

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Affiliations

Department of Mechanical Engineering The University of Texas at Dallas 800 West Campbell Rd. Richardson TX 75080 USA

Department of Chemistry and Biochemistry The University of Texas at Dallas 800 West Campbell Rd. Richardson TX 75080 USA

Department of Bioengineering The University of Texas at Dallas 800 West Campbell Rd. Richardson TX 75080 USA

Department of Radiology The University of Texas at Southwestern Medical Center 5323 Harry Hines Blvd. Dallas TX 75390 USA

Department of Surgery The University of Texas at Southwestern Medical Center 5323 Harry Hines Blvd. Dallas TX 75390 USA

References

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