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journal article·2017-09Open access

Drug Delivery: Drug‐Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling (Small 33/2017)

Mónica P. A. Ferreira, Sanjeev Ranjan, Sini Kinnunen, Alexandra Correia, Virpi Talman, Ermei Mäkilä, Brianda Barrios‐Lopez, Marianna Kemell, Vimalkumar Balasubramanian, Jarno Salonen, Jouni Hirvonen, Heikki Ruskoaho, Anu J. Airaksinen, Hélder A. Santos

Small· Volume 13· Issue 33
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Source abstract

Abstract

Coronary heart disease is the main cause of death worldwide, the endocardium being the most vulnerable region for myocardial ischemia. In article number 1701276, by Mónica P. A. Ferreira, Heikki Ruskoaho, Anu J. Airaksinen, Hélder A. Santos, and co-workers, the development of a multifunctional nanoparticle with cardioprotective potential is reported, which selectively targets the endocardial layer of the left ventricle upon intravenous injection and delivers a drug molecule for modulating the hypertrophic signaling.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Cardiovascular Disease and Adiposity · Cardiac Ischemia and Reperfusion · Cancer Research and Treatment

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki Helsinki FI‐00014 Finland

Department of Chemistry University of Helsinki Helsinki FI‐00014 Finland

Division of Pharmacology and Pharmacotherapy Faculty of Pharmacy University of Helsinki Helsinki FI‐00014 Finland

Laboratory of Industrial Physics Department of Physics University of Turku Turku FI‐20014 Finland

Helsinki Institute of Life Science HiLIFE University of Helsinki Helsinki FI‐00014 Finland

References

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