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journal article·2017-04Open access

Carbon Nanotubes: Carbon Nanotubes Disrupt Iron Homeostasis and Induce Anemia of Inflammation through Inflammatory Pathway as a Secondary Effect Distant to Their Portal‐of‐Entry (Small 15/2017)

Juan Ma, Ruibin Li, Yin Liu, Guangbo Qu, Jing Liu, Wenli Guo, Haoyang Song, Xinghong Li, Yajun Liu, Tian Xia, Bing Yan, Sijin Liu

Small· Volume 13· Issue 15
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Source abstract

Abstract

In article number 1603830, by Sijin Liu and co-workers, the exposure of multi-wall carbon nanotubes (MWCNTs) alters hepatic hepcidin-mediated systemic iron homeostasis through pro-inflammatory responses in mice, leading to limited iron availability for red blood cell formation, and eventually the development of anemia of inflammation. This study opens a new path to understanding the biological impacts of carbon nanotubes through their secondary or compensatory effects beyond the primary target tissues and organs.
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Research context

Nanomaterials

OpenAlex topics: MicroRNA in disease regulation · Biomarkers in Disease Mechanisms · Hydrogen's biological and therapeutic effects

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Affiliations

State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco‐Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Division of NanoMedicine Department of Medicine University of California Los Angeles CA 90095 USA

School of Chemistry and Chemical Engineering Shandong University Jinan 250100 China

School for Radiological and Interdisciplinary Sciences (RAD‐X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University Suzhou 215123 China

Beijing Jishuitan Hospital Peking University Health Science Center Beijing 100035 China

References

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