DataVXSmallPaper
journal article·2017-03Open access

Drug Delivery: One‐Step Microfluidic Synthesis of Nanocomplex with Tunable Rigidity and Acid‐Switchable Surface Charge for Overcoming Drug Resistance (Small 9/2017)

Qiang Feng, Jianping Liu, Xuanyu Li, Qinghua Chen, Jiashu Sun, Xinghua Shi, Baoquan Ding, Haijun Yu, Yaping Li, Xingyu Jiang

Small· Volume 13· Issue 9
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Source abstract

Abstract

In article number 1603109, Jiashu Sun, Haijun Yu, Xingyu Jiang, and co-workers utilize microfluidic chips to generate rigid pH-sensitive micellar nanocomplex (RPN) with tunable rigidity and acid-switchable surface charge for overcoming cancer drug resistance. The functionalization of RPN is realized through the incorporation of rigid PLGA core into pH-sensitive micelle. The RPN significantly enhances therapeutic efficacy against MCF-7/ADR xenograft tumor in mice, without the assistance of other therapeutic means
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for NanoScience and Technology No. 11 Beiyitiao Zhongguancun Beijing 100190 P. R. China

University of Chinese Academy of Sciences Beijing 100049 P. R. China

State Key Laboratory of Drug Research and Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 P. R. China

CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology No. 11 Beiyitiao Zhongguancun Beijing 100190 P. R. China

References

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