DataVXSmallPaper
journal article·2017-03Open access

Cancer Multidrug Resistance: Safe and Effective Reversal of Cancer Multidrug Resistance Using Sericin‐Coated Mesoporous Silica Nanoparticles for Lysosome‐Targeting Delivery in Mice (Small 9/2017)

Jia Liu, Qilin Li, Jinxiang Zhang, Lei Huang, Chao Qi, Luming Xu, Xingxin Liu, Guobin Wang, Lin Wang, Zheng Wang

Small· Volume 13· Issue 9
Publisher pageOpen full text
Source abstract

Abstract

Sericin-wrapped mesoporous silica nanoparticles (SMSNs) with pH and protease dual responsiveness are successfully fabricated as a lysosome-targeting drug delivery system by Guobin Wang, Lin Wang, Zheng Wang, and co-workers in article number 1602567. Such a dual responsive system offers a rapid doxorubicin release in lysosomes, which bypasses the membrane pump mediated drug efflux, thereby achieving the reversal of drug resistance.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Cancer therapeutics and mechanisms · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Research Center for Tissue Engineering and Regenerative Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Department of Emergency Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Department of Gastrointestinal Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Department of Clinical Laboratory Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

References

Reference metadata was not supplied for this record.