DataVXSmallPaper
journal article·2016-12

DNA Nanoparticles: Continuous Production of Discrete Plasmid DNA‐Polycation Nanoparticles Using Flash Nanocomplexation (Small 45/2016)

Jose Luis Santos, Yong Ren, John Vandermark, Maani M. Archang, John‐Michael Williford, Heng‐Wen Liu, Jason Lee, Tza‐Huei Wang, Hai‐Quan Mao

Small· Volume 12· Issue 45
Publisher page
Source abstract

Abstract

On page 6214, H.-Q. Mao and co-workers present a flash nanocomplexation (FNC) method that offers high versatility for preparing various polyelectrolyte nanoparticles in a scalable process with high efficiency and reproducibility. The cover image depicts the rapid and homogenous mixing of DNA plasmid and lPEI solutions within a confined impinging jet device, producing DNA/lPEI nanoparticles with narrow size distribution, and tunable size and shape under continuous flow operation.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: RNA Interference and Gene Delivery · Dendrimers and Hyperbranched Polymers

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Materials Science and Engineering Johns Hopkins University Baltimore MD 21218 USA

Institute for NanoBioTechnology Johns Hopkins University Baltimore MD 21218 USA

Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA

Department of Mechanical Engineering Whiting School of Engineering Johns Hopkins University Baltimore MD 21218 USA

Translational Tissue Engineering Center and Whitaker Biomedical Engineering Institute Johns Hopkins University School of Medicine Baltimore MD 21287 USA

References

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