Nanofabrication: Controllable Large-Scale Transfection of Primary Mammalian Cardiomyocytes on a Nanochannel Array Platform (Small 43/2016)

On page 5971, D. Gallego-Perez, W. Lu, L. J. Lee, and co-workers report an advanced Bio-NEMS (nanoelectromechanical system) device for high-throughput cell trapping and gene delivery on a silicon-nanochannel array chip. With a thin-film hydrodynamic approach, individual cells are precisely positioned on a nanochannel array where the molecules of well-controlled dose are delivered into each cells. The device shows potential for transfection of electrogenic cells, gene therapy, and living cell interrogation.