journal article·2015-06Open access

Crystallography: Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves (Small 23/2015)

Feng Guo, Weijie Zhou, Peng Li, Zhangming Mao, Neela H. Yennawar, Jarrod B. French, Tony Jun Huang

Small· Volume 11· Issue 23

Abstract

J. B. French, T. J. Huang, and co-workers develop a surface acoustic wave method to manipulate protein crystals for macromolecular crystallography. On page 2733, a capillary tube is coupled onto a piezoelectric substrate with a pair of interdigital transducers. When the transducers are turned on, an acoustic field is generated and introduced into the capillary through a thin layer of coupling gel. The micrometersized protein crystals suspended in the capillary will then be manipulated by the acoustic field and aligned into a linear pattern.
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Research context

OpenAlex topics: Microfluidic and Capillary Electrophoresis Applications · Microfluidic and Bio-sensing Technologies

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Affiliations

Department of Engineering Science and Mechanics The Pennsylvania State University University Park, PA 16802 USA

Department of Chemistry Stony Brook University Stony Brook, NY 11794 USA

Huck Institutes for Life Sciences The Pennsylvania State University University Park, PA 16802 USA

Department of Biochemistry and Cell Biology Stony Brook University Stony Brook, NY 11794 USA

References

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