Intracellular transport: Small 19/2009

The frontispiece shows schematically (following the arrows) the introduction of polymer microcapsules filled with fluorescently labeled peptides into a cell, the controlled opening of the intracellular capsule with an infrared laser beam, the release of the peptides from the microcapsules into the cytoplasm, the transport of peptides into the endoplasmic reticulum, the binding of the peptides to major histocompatibility complex (MHC) class I molecules, and the peptide-induced surface transport of the MHC class I molecules. For more information, please read the Full Paper “Controlled Intracellular Release of Peptides from Microcapsules Enhances Antigen Presentation on MHC Class I Molecules” by S. Springer et al., beginning on page 2168.