Alleviation of Photoreceptor Degeneration Based on Fullerenols in rd1 Mice by Reversing Mitochondrial Dysfunction via Modulation of Mitochondrial DNA Transcription and Leakage (Small 44/2023)

Junling Yang; Xia Chen; Luodan A; Hui Gao; Maoru Zhao; Lingling Ge; Minghui Li; Cao Yang; Yu Gong; Zhanjun Gu; Haiwei Xu

doi:10.1002/smll.202370366

journal article·2023-11Open access

Alleviation of Photoreceptor Degeneration Based on Fullerenols in rd1 Mice by Reversing Mitochondrial Dysfunction via Modulation of Mitochondrial DNA Transcription and Leakage (Small 44/2023)

Junling Yang, Xia Chen, Luodan A, Hui Gao, Maoru Zhao, Lingling Ge, Minghui Li, Cao Yang, Yu Gong, Zhanjun Gu, Haiwei Xu

Small· Volume 19· Issue 44

Publisher page Open full text

Source abstract

Abstract

Reversed Mitochondrial Dysfunction Fullerenol nanoparticles are both stable and effective in protecting the degenerating retina. In article number 2205998, Yu Gong, Zhanjun Gu, Haiwei Xu, and co-workers propose the potential utility of fullerenols for safeguarding the mitochondrial genome to maintain electron transport chain function and simultaneously reversing the abnormal nuclear DNA expression patterns. The nanomaterials alleviate photoreceptor degeneration and are expected to serve as a viable means to treat retinitis pigmentosa.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Photoreceptor and optogenetics research · Anesthesia and Neurotoxicity Research · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Southwest Eye Hospital, Southwest Hospital Third Military Medical University (Army Medical University) Chongqing 400038 China

Key Lab of Visual Damage and Regeneration & Restoration of Chongqing Southwest Eye Hospital Southwest Hospital Chongqing 400038 China

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience Institute of High Energy Physics and National Center for Nanoscience and Technology Chinese Academy of Sciences Beijing 100049 China

College of Materials Science and Optoelectronic Technology University of Chinese Academy of Sciences Beijing 100049 China

Department of Ophthalmology Medical Sciences Research Center University‐Town Hospital of Chongqing Medical University Chongqing 400038 China

References

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