Anti‐Tumor Nanoplatforms: M2‐Like TAMs Function Reversal Contributes to Breast Cancer Eradication by Combination Dual Immune Checkpoint Blockade and Photothermal Therapy (Small 13/2021)

In article number 2007051, Shuo Shi, Chunyan Dong, and co-workers present a stimuli-responsive multifunctional anti-tumor nanoplatform. Its photothermal effect ablates local tumor cells while strengthening infiltration of T lymphocytes. The released AUNP-12 and PQ912 remarkably relieve both the innate and adaptive immunosuppression in the tumor microenvironment. The synergized photothermal and dual immune checkpoint blockading therapy might open new insights in eliminating breast cancer. Just like a scene in the famous Chinese novel “The Pilgrimage to the West”, the god—Sun Wukong cleverly restores the “heat” of the tumor microenvironment conjuring two eagles taking the “cold dragon” away and finally burning the monster.