Polyprodrug Antimicrobials: Polyprodrug Antimicrobials: Remarkable Membrane Damage and Concurrent Drug Release to Combat Antibiotic Resistance of Methicillin‐Resistant Staphylococcus aureus (Small 41/2018)

In article number 1802008, Da Xing, Xianglong Hu, and co-workers propose a strategy of polyprodrug antimicrobials. The triclosan polyprodrug antimicrobials with diverse hydrophilic-hydrophobic balance demonstrate remarkable membrane damage and concurrent triclosan release potency, which can efficiently inhibit methicillin-resistant Staphylococcus aureus, a highly pathogenic bacteria associated with high mortality rates. Polyprodrug antimicrobials possess excellent antibacterial selectivity and undetectable antibiotic resistance when compared with commercial antibiotics.